Causes

There's no single cause of borderline personality disorder (BPD) and it's likely to be caused by a combination of factors.

Genetics

Genes you inherit from your parents may make you more vulnerable to developing BPD as there is evidence that the condition can run in families.

Problem with brain chemicals

It's thought that many people with BPD have something wrong with the neurotransmitters in their brain, particularly serotonin.

Neurotransmitters are "messenger chemicals" used by your brain to transmit signals between brain cells. Altered levels of serotonin have been linked to depression, aggression and difficulty controlling destructive urges.

Problem with brain development

Researchers have used MRI to study the brains of people with BPD. MRI scans use strong magnetic fields and radio waves to produce a detailed image of the inside of the body.

The scans revealed that in many people with BPD, 3 parts of the brain were either smaller than expected or had unusual levels of activity. These parts were:

• the amygdala - which plays an important role in regulating emotions, especially the more "negative" emotions, such as fear, aggression and anxiety
• the hippocampus - which helps regulate behaviour and self-control
• the orbitofrontal cortex - which is involved in planning and decision making

Problems with these parts of the brain may well contribute to symptoms of BPD.

The development of these parts of the brain is affected by your early upbringing. These parts of your brain are also responsible for mood regulation, which may account for some of the problems people with BPD have in close relationships.

Environmental factors

A number of environmental factors seem to be common and widespread among people with BPD. These include:

• being a victim of emotional, physical or sexual abuse
• being exposed to long-term fear or distress as a child
• being neglected by 1 or both parents
• growing up with another family member who had a serious mental health condition, such as bipolar disorder or a drink or drug misuse problem

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